Simulated data

Introduction:

These simulations start with a set of observed lineage tree topologies from lymph node samples from each of four individuals (M2, M3, M4 and M5 from Stern et al. 2014), and generate a simulated data set for each individual (R1, R2, R3 and R4, respectively) by randomly selecting a new germline sequence for every lineage and then stochastically re-introducing mutations along the lineage branches. This process was repeated 10 times for each individual to create a collection of 40 simulated data sets

The simulated data is available for downloading below.

Simulated data [zip]

Citing:

Stern, Joel NH, Gur Yaari, Jason A. Vander Heiden, George Church, William F. Donahue, Rogier Q. Hintzen, Anita J. Huttner et al. "B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes." Science translational medicine 6, no. 248 (2014): 248ra107-248ra107.