CLIP: Detecting Selection in IgV Sequences

Detecting selection in Ig V region sequences

This tool implements the Focused test as described in Uduman M et al. (2011).
If you require the Hershberg U et al. (2008) version please visit: http://clip.med.yale.edu/selection2008

Enter Ig sequences to analyze:

[Upload Ig Sequences]

FWR/CDR Boundaries

IMGT®
IMGT® No CDR3
Custom

	Start	End

Use our germline identification tool for assistance with identifying germline & IMGT-aligning

Species:

Alpha (P-value) cut-off:

Input formatting:

Input sequences are clonally related

Include results from the Local & Global tests for selection

Compute P-values using original binomial based test as described in Hershberg et al., 2008

*Click on respective field names for Help

For further information on the methods, or if you use the results of this website, please cite the following papers:

Uri Hershberg; Mohamed Uduman; Mark J. Shlomchik; Steven H. Kleinstein. Improved methods for detecting selection by mutation analysis of Ig V region sequences. International Immunology. 2008 May;20(5):683-94

Mohamed Uduman; Gur Yaari; Uri Hershberg; Mark J. Shlomchik; Steven H. Kleinstein. Detecting selection in immunoglobulin sequences. Nucl. Acids Res. (2011) doi: 10.1093/nar/gkr413.

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